highlight / actuality
Researchers at our laboratory show for the first time that BMP9 and BMP10 inhibit the migration and proliferation of endothelial cells. They propose a transduction model of ALK1 signal. Studies realized by those researchers could be particularly interesting in the development and monitoring of anti-angiogenic therapies.
Highlight available in French.
David L, Mallet C, Mazerbourg S, Feige JJ and Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood, 2007
Lamouille S, Mallet C, Feige JJ and Bailly S. Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis. Blood, 2002
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.