Angiogenesis and lymphangiogenesis, which correspond to the formation of new blood and lymphatic vessels from existing vessels, are two major processes involved in physiological development, but also in tumoral development and metastatic dissemination. To address this question, the team is working on a new signalling pathway specific to the vascular system mediated by the transmembranous receptor ALK1.
Cell invasion is a regulated process that is physiologically active during embryonic morphogenesis, pregnancy, and wound healing. During cancer progression, deregulated cell invasion processes contribute to many steps of the metastatic dissemination, including cellular escape from primary tumors, intravasation into the blood and lymphatic vascular compartments and metastatic seeding in distant tissues.
The main focus of the team is to develop a basic research aiming at deciphering the virulence strategies used by Pseudomonas aeruginosa to promote infections. More specifically, the goal is to understand the molecular mechanisms this human opportunistic pathogen employs to colonize organs and to eventually cross epithelial and endothelial barriers, leading to acute and chronic infections.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.