highlight / actuality
Angiogenesis is the formation of new blood vessels from existing blood system. Tumors promote their own vascularization. The understanding of the mechanisms that regulate angiogenesis and the identication of the key molecules involved should allow to identify new therapeutic targets in order to combat and control angiogenesis and therefore cancer. Such a molecule that inhibits the neo-angiogenesis was characterized in our laboratory. This molecule, BMP9, therefore represents an important tool in the pathologies where angiogenesis is implicated as in the cancer.
 Bailly S
HHT is not a TGFß disease.
 David L, Mallet C, Keramidas M, Lamandé N, Gasc JM, Dupuis-Girod S, Plauchu H, Feige JJ and Bailly S
Bone morphogenetic protein-9 is a circulating vascular quiescence factor.
Circulation Research, 2008
 David L, Mallet C, Mazerbourg S, Feige JJ and Bailly S
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.