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We show that the phosphorylation of two TIS11b serines have antagonistic effects on the destabilizing function of the mRNAs of this protein. Characterizing the impact of these multiple phosphorylations on the activation or inhibition of mRNA degradation is necessary in order to better understand the impact of their dysregulation in human pathologies, particularly in cancer.
Thesis presented December 12, 2014 by Felicitas Rataj. PhD thesis available as a pdf file.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.