highlight / actuality
We show how ExlA, a new toxin found in a strain of
P. aeruginosa, causes necrosis of epithelial and endothelial cells in the lungs of infected mice and causes hemorrhagic pneumonias and allows dissemination of the bacteria in the body.
Researchers from the laboratory have identified strains of
P. aeruginosa with a new toxin: ExlA that forms pores in the plasma membrane. They show in this new study that this bacterial weapon causes the necrosis of epithelial and endothelial cells in the lungs of infected mice. This toxin causes haemorrhagic pneumonia and allows bacterial dissemination in the body (Figure). The ExlA secreting strain can proliferate in the lungs because it does not induce the production of pro-inflammatory cytokines and does not trigger an immune response sufficient to be destroyed. On the other hand, when the blood system of mice is infected, the bacterium is rapidly destroyed because it is in the direct presence of neutrophils and the complement system.
Thesis presented on October 24, 2017 by Pauline Basso. PhD thesis available as a pdf file.
Thesis presented on October 12, 2017 by Emeline Reboud. PhD thesis available in pdf format.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.