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Discovery and description of a novel virulence strategy of clinical strains

Published on 19 February 2020
Until 2014, it was widely admitted in the Pseudomonas community, that the main pathogenic mechanism of P. aeruginosa requires T3SS.
This dogma was challenged when we discovered a novel toxin, named Exolysin (ExlA) required for cell and tissue destruction [8].
We demonstrated that ExlA possesses a pore-forming activity, leading to cell death [9].
In collaboration with Dessen’s team (IBS) we gained knowledge on the ExlA structure-function relationship.


Partial structural model of the ExlA based on homologous TPS elements present in the Protein Data Bank.
Reboud et al., Toxins, 2017

References
[8] Elsen et al (2014) Cell host & microbe 15(2):164-176.,
[9] Basso et al (2017) mBio 8(1).,