Until 2014, it was widely admitted in the Pseudomonas community, that the main pathogenic mechanism of
P. aeruginosa requires T3SS.
This dogma was challenged when we discovered a novel toxin, named Exolysin (ExlA) required for cell and tissue destruction
[8].
We demonstrated that ExlA possesses a pore-forming activity, leading to cell death
[9].
In collaboration with Dessen’s team (IBS) we gained knowledge on the ExlA structure-function relationship.
Partial structural model of the ExlA based on homologous TPS elements present in the Protein Data Bank.
Reboud
et al.,
Toxins, 2017
References
[8] Elsen
et al (2014)
Cell host & microbe 15(2):164-176.,
[9] Basso
et al (2017)
mBio 8(1).,