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Metals to treat cancer?

A successful collaboration between chemists and biologists has identified the action of a new class of molecules, polyoxometalates, mainly composed of metals and oxygen. These molecules inhibit specifically and in a very powerful way the protein kinase CK2, a hyperactivated enzyme in many cancers. The crucial role of this enzyme in controling the proliferation and cell survival makes it an important target for drug discovery.

Published on 17 July 2008
​These results have been published in the journal Chemistry and Biology by chemists from the Institute of Molecular Chemistry (CNRS / UPMC) and biologists from our Institute (CEA / CNRS / Inserm / Joseph Fourier University)

Press release available in French.

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